Using Molecular Patterns to Inform Individualized Prescription
Zachary S Clayton and Kevin O Murray
The Journal of Clinical Endocrinology & Metabolism, Volume 109, Issue 9, September 2024, Pages e1800–e1801
https://doi.org/10.1210/clinem/dgae076
Despite the well-established metabolic health benefits of aerobic exercise training, there is a select group of individuals that experience limited metabolic improvements with structured aerobic exercise training compared to those that readily acquire these benefits. As such, the terms “high responders” and “low responders” have emerged. Understanding this heterogeneity in responsiveness to aerobic exercise training has become particularly relevant to the field of personalized/precision medicine as it is clear that aerobic exercise training interventions cannot be advanced using a “one-size-fits-all” approach. The field of precision medicine, including personalized exercise prescription, is rapidly expanding with the rise of cutting-edge high-throughput “omics” analyses and artificial intelligence; however, before it can be broadly adopted, select considerations should be made.
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