Ben Broos, Sara Charleer, Nancy Bolsens, Carolien Moyson, Chantal Mathieu, Pieter Gillard, Christophe De Block
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3037–e3048
https://doi.org/10.1210/clinem/dgab188
To investigate whether diabetes knowledge and health literacy impact glycemic control after 1 year of intermittently scanned continuous glucose monitoring (isCGM) in people with type 1 diabetes ≥ 16 years.
In this prospective real-world cohort study, we assessed diabetes knowledge using a new 10-item questionnaire [Patient Education and Knowledge (PEAK)] and health literacy using the validated 6-item Newest-Vital Sign-D (NVS-D) questionnaire. Primary endpoint was association between PEAK score and change in hemoglobin A1c (HbA1c). Secondary endpoints were link between NVS-D score and change in HbA1c and that between time spent in/above/below range and PEAK/NVS-D scores.
851 subjects were consecutively recruited between July 2016 and July 2018. Median PEAK score was 8 (range: 0–10), and median NVS-D score was 6 (range 0–6). HbA1c evolved from 7.9% (7.8%–8.0%), 63 (62–64) mmol/mol, at start to 7.7% (7.6%–7.7%), 61 (60–61) mmol/mol (P < 0.001), at 6 months and to 7.8% (7.7%–7.9%), 62 (61–63) mmol/mol, at 12 months (P < 0.001). HbA1c only improved in subgroups with higher scores [PEAK subgroups with score 7–8 (P = 0.005) and 9–10 (P < 0.001) and NVS-D score 4–6 (P < 0.001)]. At 12 months, time spent below 70 mg/dL was reduced by 15% (P < 0.001), and time spent below 54 mg/dL was reduced by 14% (P < 0.001), irrespective of PEAK/NVS-D score. Multiple linear regression analysis demonstrated an association of PEAK score, scan frequency, and baseline HbA1c with evolutions in time in range and time in hyperglycemia.
isCGM reduced time in hypoglycemia, and HbA1c evolved favorably. Our findings suggest that diabetes and health literacy affect glucometrics, emphasizing the importance of education.
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