Lipids in Adult Women With Turner Syndrome

Kristian Juul Sandahl, Jesper Just, Mogens Erlandsen, Kristian Havmand Mortensen, Niels Holmark Andersen, Claus Højbjerg Gravholt
Journal of the Endocrine Society, Volume 7, Issue 11, November 2023, bvad124
https://doi.org/10.1210/jendso/bvad124

Abstract

Context

Turner syndrome (TS) is a rare genetic syndrome with an increased mortality, mainly attributed to cardiovascular disease.

Objective

This work aimed to investigate and correlate the lipid profile in adult women with TS to clinical characteristics.

Methods

A 12-year prospective cohort study, including 4 study visits, was conducted at a specialist hospital. A total of 102 women with TS qualified for inclusion. Excluding missing variables and participants lost to follow-up, 86 women (mean age 38.1 years; range, 18.4-62.1 years) were included in this study. Fifty-three women completed the study. Repeated-measurement analysis was performed, using total cholesterol (Total-C), low-density lipoprotein (LDL), triglycerides (TGs), and high-density lipoprotein (HDL) as outcome variables and age, karyotype, body mass index (BMI), treatment with statins, antidiabetics, and hormone replacement therapy as explanatory variables. Principal component analysis (PCA) and partial least squares (PLS) analysis were performed at the first study visit.

Results

Hyperlipidemia was present in 30% of the TS cohort. Total-C increased with age (0.12 mmol/L/y; P = .016). LDL (P = .08), TGs (P = .14), and HDL (P = .24) were not associated with age. BMI significantly increased total-C (0.19 mmol/L/kg/m²; P = .006), LDL (0.63 mmol/L/kg/m²; P < .001), and TGs (0.80 mmol/L/kg/m²; P < .001) and decreased HDL (−0.59 mmol/L/kg/m²; P < .001). PCA and PLS analysis found correlations between weight and BMI and total-C, LDL, and TGs.

Conclusion

Hyperlipidemia is more prevalent in adult women with TS across adulthood compared to the background population. Total-C, LDL, TGs, and HDL were significantly associated with BMI characterizing the atherogenic profile in adult women with TS.

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