an Endocrine Society Thematic Issue
Read our special collection of journal articles, published in 2022–2023, focused on bone research! Curation of the collection was guided by Altmetric Attention Scores and Featured Article designations.
In Journal of the Endocrine Society, Mullin and colleagues describe a functional assessment of calcium-sensing receptor variants from probands provisionally diagnosed with familial hypocalciuric hypercalcemia. It enabled investigators to rule out primary hyperparathyroidism, which can cause osteopenia and osteoporosis. Tests could demonstrate impaired expression of the mature receptor produced by the variant genes. Hamilton and patient coauthors provide a perspective on the needs of patients with X-linked hypophosphatemia, stressing the importance of clinical education and whole-life care. Chuki and associates report frequent disease recurrence in a long-term study of patients treated for primary hyperparathyroidism by autografts of parathyroid tissue into muscle.
In Endocrinology, Daley et al. report the use of a homologous recombination-based knock-in technique to generate a mouse model in which complementary DNA encoding the human parathyroid-1 receptor replaces a segment of the equivalent murine gene, so the human protein is expressed; the model can be used to evaluate the pharmacologic properties of ligands. Hasegawa and colleagues report that the oral calcimimetic evocalcet rescues secondary hyperparathyroidism-driven bone cortical porosity in male rat models of chronic kidney disease. Jiang and associates report data suggesting that intestinal vitamin D receptor in adult mice prevents bone loss during low calcium intake but is dispensable during adequate calcium intake.
In JCEM, Komaba and colleagues report that parathyroidectomy led to better long-term outcomes than cinacalcet treatment in patients with secondary hyperparathyroidism receiving hemodialysis. Seib et al. describe how in a predominantly male cohort with primary hyperparathyroidism, patients treated by parathyroidectomy continued to be at higher risk of kidney stone events in the immediate years after treatment than patients managed nonoperatively, although the adjusted risk of kidney stone events declined with time. Wu et al. report on a study of the long-term effects of medical therapy on over 46,000 patients over 40 who had an osteoporotic fracture. Long-acting zoledronic acid provided the lowest mortality of all the medications studied, with denosumab and alendronate/risedronate also providing improvements over raloxifene and bazedoxifene.
In Endocrine Reviews, Schini and associates assess the benefits from increasing use of bone turnover markers in research and clinical practice. Jha and Simonds review the molecular and clinical spectrum of primary hyperparathyroidism, which in rare cases may be caused by parathyroid carcinoma. And Saul and Khosla summarize the physiological as well as pathological processes during fracture healing in endocrine disease and aging, with the goal of establishing a broad understanding of the biomechanical and molecular mechanisms involved in bone repair.
Published: June 2023
It can be difficult to keep up to date in the rapidly evolving and expanding world of endocrine science. We curate topical collections of research from across our journals, Endocrine Reviews, Endocrinology, Journal of the Endocrine Society, The Journal of Clinical Endocrinology & Metabolism, and JCEM Case Reports so that you can easily find and read recent, influential articles on the topics that interest you.
Selection in each Thematic Issue is guided by online metrics, including Altmetric Attention Scores, Featured Article designations, and identification of leading authors and key topics. Each month, we publish a new Thematic Issue online and work to highlight and promote endocrine science in the press, through email, on social media and across other distribution channels.
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