an Endocrine Society Thematic Issue
Read our special collection of journal articles focused on diabetes! These were published in 2023 and 2024, with curation guided by article downloads, Altmetric Score, and Featured Article designation.
In Journal of the Endocrine Society, Kjeldsen and coauthors present data indicating that improvements in glucagon resistance may depend on body weight loss in patients with type 2 diabetes. Jia and Yu review recent progress in the analysis of islet antibodies to neoantigens and neoepitopes, which may predict the course of type 1 diabetes. Tajima et al. report that possible sarcopenia, judged by low handgrip strength, and insulin resistance, assessed by the triglyceride index, are independently associated with type 2 diabetes in older Japanese individuals, with their coexistence particularly strongly associated.
In JCEM Case Reports, Sahota and associates describe a patient who, when treated for macroprolactinoma with a dopamine agonist, was able to stop insulin treatment of his autoimmune diabetes for 2 years. Thewjitcharoen and colleagues report on a patient being treated with metformin for type 2 diabetes who developed severe vitamin B12 deficiency that led to acute-on-chronic subdural hematoma resulting from frequent falls. Koutnik et al. detail how a ketogenic diet followed for ten years lowered the insulin requirement and produced other benefits in a patient with type 1 diabetes.
In Endocrinology, Ivovic and coauthors provide evidence from mouse and rat experiments that β-cell insulin resistance plays a causal role in free fatty acid-induced β-cell dysfunction. Toledo and colleagues give a comprehensive characterization of islet remodeling in development and in diabetes, using mass cytometry data from the Human Pancreas Analysis Program. Fujita and associates describe experiments showing that the loss of dectin-2, a receptor found within islets, promotes inflammation and impairs insulin secretion, effects mediated by proinflammatory cytokines.
In Endocrine Reviews, Yu et al. discuss the clinical, biochemical, and molecular mechanisms that may underlie endogenous factors that are protective for diabetes, as well as the roles such factors could play in chronic complications. Conte and coathors review the interrelationships between diabetes, energy metabolism, and COVID-19, noting various ways in which the COVID-19 pandemic might worsen the diabetes pandemic. Rosenstock and associates analyze the basis for weekly insulin therapy, examining evidence gained using insulin icodec and insulin efsitora alfa.
In JCEM, Silva and colleagues report on a 12-year follow-up study of metabolites associated positively and negatively with diabetic retinopathy in patients with type 2 diabetes, finding multiple examples of each type that could become biomarkers. Uhl et al. present a systematic review and meta-analysis synthesizing the findings of randomized controlled trials of continuous glucose monitors in the management of adults with type 2 diabetes. Agbaje describes the interactive effects of sedentary time, physical activity, and fat mass on insulin resistance in a young population enrolled in the Avon Longitudinal Study of Parents and Children, UK.
Published: October 2024
It can be difficult to keep up to date in the rapidly evolving and expanding world of endocrine science. We curate topical collections of research from across our journals, Endocrine Reviews, Endocrinology, Journal of the Endocrine Society, The Journal of Clinical Endocrinology & Metabolism, and JCEM Case Reports so that you can easily find and read recent, influential articles on the topics that interest you.
Selection in each Thematic Issue is guided by online metrics, including Altmetric Attention Scores, Featured Article designations, and identification of leading authors and key topics. Each month, we publish a new Thematic Issue online and work to highlight and promote endocrine science in the press, through email, on social media and across other distribution channels.
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