an Endocrine Society Thematic Issue
Read our special collection of journal articles, published in 2020 and 2021, focused on women’s health research! Curation of the collection was guided by Altmetric Attention Scores and Featured Article designations.
In Journal of the Endocrine Society, a retrospective cohort study by Rasmussen et al. finds an increased risk of type 2 diabetes in women with elevated levels of plasma testosterone. Al Khalifah and coauthors compare the efficacy of metformin and oral contraceptive pills, in combination with other drugs, as treatments for polycystic ovary syndrome (PCOS) in adolescents. Alvarado and colleagues report that in women, factors affecting insulin sensitivity, rather than maternal gestational weight gain, seem to account for the changes in glucose metabolism during pregnancy. Andrisse et al. report that adolescents with PCOS show similar racial and ethnic variation to the general population, in terms of metabolic disease components.
JCEM carries a report from Dhillon-Smith and co-workers on the prevalence of thyroid dysfunction in women with a history of subfertility or miscarriage: A lowered cut-off for thyroid-stimulating hormone defines a population whose fertility could improve with treatment of subclinical hypothyroidism. Jacobson et al. find that levels of two phthalates in the urine of pregnant women correlate with changes in progesterone level, with one of these endocrine-disrupting chemicals also correlating with post-partum depression. Berni and coauthors find that young women with PCOS have an increased risk of major cardiovascular events, including myocardial infarction, angina, and revascularization. Riestenberg et al. find in a meta-analysis that PCOS leads to an $8 billion annual economic burden in the USA (in 2020 dollars).
In Endocrinology, Sreekumar and colleagues report significant differences between the responses of invasive ductal breast carcinoma and invasive lobular carcinoma cells to two selective estrogen receptor downregulators. DiStefano reviews nonalcoholic fatty liver disease and nonalcoholic steatohepatitis in postmenopausal women, who lose some of the protection that benefits premenopausal women. De Bem et al. describe the use of an endometrium-on-a-chip microfluidics approach to produce a multicellular endometrium in vivo and investigate its response to different glucose and insulin concentrations. Mogus and co-workers report evidence that propylparaben at levels relevant to human exposure interferes with the effect of parity in mice and induces long-term changes in the mammary gland.
In Endocrine Reviews, Padmanabhan et al. discuss the importance of maternal and fetal exposure to endocrine-disrupting chemicals in disrupting the maternal-fetal milieu, with the consequent risk of adverse pregnancy and birth outcomes; these include adult-onset noncommunicable diseases. Di Clemente and co-authors review the role of anti-Müllerian hormone in female reproduction, including its regulation of folliculogenesis, neuroendocrine effects, and involvement in PCOS. Flores, Pal, and Manson review concepts and controversies in the prescription of hormone therapy for menopausal symptoms. And Andersson and Braegger describe advances in the understanding of iodine nutrition and its association with thyroid function in lactating women, infants, and toddlers.
Published: January 2022
It can be difficult to keep up to date in the rapidly evolving and expanding world of endocrine science. We curate topical collections of research from across our journals, Endocrine Reviews, Endocrinology, Journal of the Endocrine Society, and The Journal of Clinical Endocrinology & Metabolism, so that you can easily find and read recent, influential articles on the topics that interest you.
Selection in each Thematic Issue is guided by online metrics, including Altmetric Attention Scores, Featured Article designations, and identification of leading authors and key topics. Each month, we publish a new Thematic Issue online and work to highlight and promote endocrine science in the press, through email, on social media and across other distribution channels.
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