The goal of the 1st International Conference on Steroid Hormones and Receptors (SHR 2024) is to present and discuss advances in steroid hormone action in biology and medicine, exploring their role in biology, chemistry, pharmacology, oncology, neurology, metabolism, cardiovascular biology and endocrinology. The conference will feature Plenary and Keynote Lectures, oral presentations and posters by prominent and emerging leaders as well as trainees in the field. Conference proceedings will be published in an international peer-reviewed journal. Sessions will cover (but are not limited to) the following topics:
- Cancer Biology and Therapeutics
- Cardiovascular Biology and Disease
- Neurobiology and Aging
- Metabolism and Comorbidities
- Molecular and Structural Biology of Steroid Receptors
- Immune System and Inflammation
- Systems Biology and Cell Signaling Networks
Schedule at a Glance
The schedule and tiles below are tentative. Check this page in leadup to our meeting for new updates on our program.
Tuesday, October 15th
- 6:00-8:00 PM MT - Welcome Reception at Outpost 1706 in Old Town Albuquerque (Optional)
Wednesday, October 16, 2024
- 8:30-9:45 AM MT – Registration and Breakfast
- 9:45 AM MT – Welcome and Opening Remarks
- 10:00-11:00 AM MT – Opening Keynote
- Elucidation of the Mechanisms by Which Cells Recognize and Respond to Different Levels of Steroid Hormones to Elicit Different Biological Responses
- Faculty: Donald McDonnell, PhD
- 11:00 AM-12:00 PM MT – Programming & Reprogramming I: SRs in Health and Disease States
Session Chair: Carol Lange, PhD
- Transcriptional and Epigenomic Programming of Homeostatic Macrophages
- Faculty: Inez Rogatsky, PhD
- Steroid Hormone Action in Endometrial Cancer
- Androgen Receptor Action in ER+ Breast Cancer – New Preclinical and Clinical Trial Findings
- Faculty: Jennifer Richer, PhD
- 12:00-1:00 PM MT – Lunch and Networking
- 1:00-3:00 PM MT – Feeding the Heart’s Desire: SRs in Cardiovascular Biology & Other High Places
Session Chair: Matthias Barton, MD
- Proatherogenic Actions of Estrogen Receptors in Endothelium
- Faculty: Philip Shaul, MD
- Exploring Chemokine Receptors in the Genesis of Aldosterone and Mineralocorticoid Receptor-Induced Cardiovascular Injury
- Faculty: Thiago Bruder do Nascimento, PhD
- Different Levels of Rapid ER Activation of the Anticipatory-UPR Authorize Estrogen-ER-regulated Transcription or Induce Death of Cancer Cells
- Faculty: David Shapiro, PhD
- Crosstalk Between Steroid Hormones and Maf1: Implications for Cancer and Aging
- Faculty: Carol Sartorius, PhD
- Location, Location, Location…Spatial Biology of Hormone-Dependent Cancer Disparities
- Faculty: Zeynep Madak-Erdogan
- 3:00-4:15 PM MT – Poster Session I and Networking Break
- 4:15-5:15 PM MT – Oral presentations from Abstracts
Session Chair: Jay Gertz, PhD
- A Common Polymorphism Allows Nuclear Receptors to Activate WNT4 Signaling to Drive Aggressive Phenotypes in Ovarian Cancer
- Presenter: Madeleine Shackleford
- ARID1A Suppresses Proliferative Signaling Driven by Estrogen Receptor Alpha in Endometrial Cancer
- Presenter: Jacob Polaski, PhD
- Blockade of Tumor Glucocorticoid Recycling Suppresses Regulatory T Cells to Inhibit Tumor Growth
- Presenter: Matthew Taves, PhD
- Nuclear Receptors Dynamics and Gene Regulation in Response to Ultradian Hormone Pulses
- Presenter: Diana Stavreva, PhD
Thursday, October 17, 2024
- 8:00-9:00 AM MT – Breakfast and Networking
- 9:00-9:15 AM MT – Opening Remarks
- 9:15-10:15 AM MT – Scratching the Surface: SR Signaling Actions & Cell Fate
Session Chair: Kimberly Leslie, MD
- Steroid Receptor Coactivator Complexes Regulate Breast Cancer Stem-Like Pathways in Therapy Resistant ER+ Breast Cancer
- Faculty: Julie Ostrander, PhD
- Testosterone Acts Through Membrane Protein GPRC6A to Cause Cardiac Phenotypes in Zebrafish Embryos
- Faculty: Daniel Gorelick, PhD
- Nuclear and Membrane Esr1 Signaling Are Essential for Early-Life Prostate Reprogramming by Estrogen
- 10:15 AM-11:15 PM MT –Through the Looking Glass: SR Structure & Functional Insights
Session Chair: Zeynep Madak-Erdogan, PhD
- A Novel SERM Influences a Paracrine Factor Associated with Metastasis in Y537S ESR1 Breast Cancer Cells
- Faculty: Sean Fanning, PhD
- Oligomerization Changes Driven by Antagonist-to-Agonist Switch in MR
- Faculty: Diego Alvarez de la Rosa, PhD
- Structure-Informed Discovery of a Novel Nuclear Receptor Ligand Regulatory Mechanism
- Faculty: Douglas Kojetin, PhD
- 11:15 AM-12:15 PM MT – Oral presentations from Abstracts
Session Chair: Kristy Brown, PhD
- Estrogen Receptor Mutants with Endocrine Therapies Stabilize Multiple Receptor Antagonist Substates to Drive Efficacy and Resistance
- Loss of Erα Phosphorylation at Serine 167 And Serine 212 Alters the Erα Transcriptome/Cistrome, Impacting Breast Cancer Growth, Tamoxifen Response, Mouse Fertility, Aging and Metabolism
- Regulation of Super Enhancers by Phosphorylated Progesterone Receptors Drives Breast Cancer Stem Cell Expansion
- Presenter: Noelle Gillis, PhD
- Targeting the Glucocorticoid Receptor Solvent Channel for Modulation of Activity
- Presenter: Robin Russo Kobylski
- 12:15-1:15 PM MT – Lunch and Networking
- 1:15-3:15 PM MT – Staying as Young as you Feel: SRs in Neurobiology, Metabolism & Aging
Session Chair: Marc Tetel, PhD
- The Metabolic and Behavioral Outcomes of a Preclinical Model of Estrogen Gender-Affirming Hormone Therapy
- Faculty: Troy Roepke, PhD
- The Effects of Estradiol Therapy on Cognition in Women with Early Life Ovarian Removal
- Faculty: Noelia Calvo, PhD
- Estrogenic Modulation of Neural Circuits that Control Energy Expenditure
- Faculty: Stephanie Correa, PhD
- Mineralocorticoid Receptor and Metabolic Diseases: A Closer Look at the Adipocyte
- Faculty: Massimiliano Caprio, MD, PhD
- Sensitizing B-cell Acute Lymphoblastic Leukemia to Treatment with Glucocorticoids
- Faculty: Miles Pufall, PhD
- 3:15-4:15 PM MT – Poster Session II and Networking Break
- 4:15-5:45 PM MT – Programming & Reprogramming II: Targeting SR Drivers of Altered Cellular States
Session Chair: Jennifer Richer, PhD
- Understanding Lobular Breast Cancer as a Distinct Genomic Environment for Estrogen Receptor Activity
- Faculty: Matthew Sikora, PhD
- The Role of Obesity-Related Estrogens in Driving DNA Damage in the Breast Glands of BRCA1 and BRCA2 Mutation Carriers
- Faculty: Kristy Brown, PhD
- Combining AR and GR Antagonism in Prostate Cancer
- Faculty: Suzanne Conzen, MD
Friday, October 18, 2024
- 8:30-9:15 AM MT – Breakfast and Networking
- 9:15-9:30 AM MT – Closing Day Updates
- 9:30-10:30 AM MT – Hitting Above and Below the Belt: SRs in the Brain, Microbiome, and Reproductive Tract
Session Chair: Carol Sartorius, PhD
- Time to Get Serious About Endometrial Cancer: Hormone-Dependent Disease Incidence and Mortality Rates are on the Rise!
- Faculty: Kimberly Leslie, MD
- Estrogens and the Gut Microbiome
- Promiscuous Behaviors of Nuclear Receptors Leads to Unique Transcriptomes in Human Cells and Animals
- Faculty: John Cidlowski, PhD
- 10:45-11:45 AM MT – Closing Keynote
- Broadening our Understanding of Estrogen Signaling in Female Physiology Beyond Breast Cancer
- Faculty: Holly Ingraham, PhD
- 11:45 AM MT – Awards Ceremony and Closing Remarks
- 12:00 PM MT – Grab and Go Lunch
