Podcast Journal Club

Testosterone Levels and Fracture Risk in Men

March 20, 2025

EFL059

Join host Chase Hendrickson, MD, from Vanderbilt University Medical Center, in a discussion about a recent investigation in The Journal of Clinical Endocrinology & Metabolism that tries to illuminate the relationship between serum testosterone and fractures in men. Ever since the release of the TRAVERSE fracture findings last year, we as endocrinologists have been uncertain in how to think about testosterone and bone health, as that trial made us question what we thought we already knew. So we thought that this article would be an important one to review and are eager to discuss it. Dr. Hendrickson talks with Anna Goldman, MD, from Harvard Medical School and guest expert Peter J. Snyder, MD, from the University of Pennsylvania. The article featured this month, by Grahnemo et al, was first published in JCEM in October 2024: “Associations of Serum Testosterone and SHBG With Incident Fractures in Middle-Aged to Older Men.”

Meet the Speakers

Peter Snyder and Anna Goldman

Peter J. Snyder, MD, is professor of medicine at the University of Pennsylvania in the Division of Endocrinology, Diabetes and Metabolism. He graduated from Harvard Medical School and was a resident in medicine at the Beth Israel Hospital and a fellow in endocrinology at the University of Pennsylvania. Dr. Snyder has been on the faculty of the University of Pennsylvania since 1971. He has had a longstanding interest in pituitary adenomas and a longstanding interest in male reproductive endocrinology and the effect of testosterone on bone. He was the principal investigator of The Testosterone Trial, a randomized, placebo-controlled study of the efficacy of testosterone on 800 elderly men with low testosterone. He was also the principal investigator of the fracture trial of the TRAVERSE Trial. He is co-editor-in-chief of UpToDate in Endocrinology and Diabetes and an elected member of the American Society for Clinical Investigation and the Association of American Physicians. He received the 2023 Outstanding Clinical Investigator Award of the Endocrine Society.

Anna Goldman, MD, received her medical degree from the Perelman School of Medicine at the University of Pennsylvania. She trained in internal medicine at the Icahn School of Medicine at Mount Sinai, where she also served as chief resident. She did her fellowship training in endocrinology at Brigham and Women’s Hospital (BWH), during which she conducted research in andrology. Dr. Goldman was the associate program director for the endocrinology fellowship training program at BWH for many years. She is an instructor of medicine at Harvard Medical School and is now in practice at Atrius Health. Her career focus is on patient care in the areas of andrology, transgender care, diabetes, and medical education.


Meet the Host

Chase HendricksonChase Hendrickson, MD, MPH, practices general endocrinology at the Vanderbilt University Medical Center, where he is an associate program director for the endocrinology fellowship program. His interests include endocrine education, teaching inferential methods, and quality improvement.


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